“Princess Python (Zelda DuBois) is a fictional character, a supervillain in the Marvel Comics Universe, most notably as a member of the Circus of Crime. She has no superhuman abilities, but rather relies on her snake charming skills and her 25-foot (7.6 m) pet rock python snake. She has fought several superheroes, ranging from the Avengers to Iron Man. She is also notable as she was the first villainess that Spider-Man has faced. She first appeared in The Amazing Spider-Man #22 (Mar 1965).” (source)
More images here.